Ayush Noori

Hi! I am an undergraduate at Harvard studying Computational Neuroscience and student researcher designing machine learning and bioinformatics pipelines to decipher neurodegeneration. I currently work in the Department of Biomedical Informatics at Harvard Medical School (advised by Marinka Zitnik), the Wyss Institute for Biologically Inspired Engineering (advised by George Church), and the Institute for Neurodegenerative Disease at Massachusetts General Hospital (advised by Sudeshna Das, Alberto Serrano-Pozo, and Bradley T. Hyman).

I'm passionate about using entrepreneurship to translate academic discoveries to new therapeutics and technologies that move our world forward. Beyond my research and entrepreneurial endeavors, I'm a photography enthusiast, creative writer, and avid consumer of mangoes.

Some of my most recent work is shown below. If anything piques your interest, I would love to hear from you. Please don't hesitate to reach out! To stay updated with my work and life, you can follow me on social media.

Selected Publications

First and co-first author publications are indicated in red. For a full list of my publications, please see here.

Multimodal Learning with Graphs

Survey of 140 studies in graph-centric AI to establish a framework for multimodal graph learning.

NLP Annotation Tool to Phenotype Cognitive Status in EHR

Development and evaluation of a natural language processing annotation tool to facilitate phenotyping of cognitive status in electronic health records.

Plasma Biomarkers to Predict Cognitive Decline

Plasma biomarkers for prognosis of cognitive decline in patients with mild cognitive impairment.

Cyclic Multiplex IHC and Deep Learning to Phenotype Glia in Alzheimer's

Cyclic multiplex fluorescent immunohistochemistry and machine learning reveal distinct states of astrocytes and microglia in normal aging and Alzheimer’s disease.

APOE and Glia in Normal Aging and Alzheimer's

Effect of APOE alleles on the glial transcriptome in normal aging and Alzheimer’s disease.

Complexity of Astrocyte Reaction in Alzheimer's

Systematic review of human post-mortem immunohistochemical studies and bioinformatics analyses unveil the complexity of astrocyte reaction in Alzheimer's disease.

Active Deep Learning on EHR for Cognitive Screening

Active deep learning to detect cognitive concerns in electronic health records.

Transcriptomic Signatures of Neurodegeneration

Systematic review and meta-analysis of human transcriptomics reveals neuroinflammation, deficient energy metabolism, and proteostasis failure across neurodegeneration.

Human CNS Differential Expression across Neurodegeneration

Differential gene expression data from the human central nervous system across Alzheimer's disease, Lewy body diseases, and the amyotrophic lateral sclerosis and frontotemporal dementia spectrum.

Context-Dependent Astrocyte Reaction in Neurodegeneration

Meta-analysis of mouse transcriptomic studies supports a context-dependent astrocyte reaction in acute CNS injury versus neurodegeneration.

C. elegans Exosomes in Immunity and Aging

Composition of Caenorhabditis elegans extracellular vesicles suggests roles in metabolism, immunity, and aging.

LexA Enhancer Traps in Drosophila

An interscholastic network to generate LexA enhancer trap lines in Drosophila.

Laboratories

Zitnik Lab

Advised by Dr. Marinka Zitnik in the Department of Biomedical Informatics at Harvard Medical School, studying applied machine learning on network systems in biology and medicine.

Church Lab

Advised by Dr. George Church and Dr. Jenny Tam, applying graph AI on patient-derived cerebral organoids for drug repurposing in neuropsychiatric disorders.

MIND Data Science Lab

Advised by Dr. Sudeshna Das at the MassGeneral Institute for Neurodegenerative Disease, developing integrative computational methods in biomedical and brain research.

Entrepreneurship

Fifty Years

Biology Fellow at Fifty Years helping great scientists leverage breakthroughs in biology to found iconic companies and solve pressing global challenges.

Nucleate Dojo

Leading partnerships at Nucleate Dojo to empower the next-generation of biotechnology innovators.